Effects of pyridoxine deficiency and dl-p-chlorophenylalanine administration to rats on 5-hydroxytryptamine and noradrenaline concentrations in brain and 5-hydroxytryptamine concentration in blood
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منابع مشابه
Cathecholamine and 5-hydroxytryptamine levels in ischemic brain. Influence of p-chlorophenylalanine.
The effect of ischemia on catecholamine and 5-hydroxytryptamine (5-HT) levels in brain cortex was examined in the gerbil stroke model. Unilateral common carotid artery occlusion produced bilateral decrease in cortical dopamine levels in gerbils both symptomatic and asymptomatic of cerbral ischemia. The 5-HT progressively decreased only in the occluded hemisphere of ischemic animals. In p-chloro...
متن کاملBlood and urine 5-hydroxytryptophan and 5-hydroxytryptamine levels after administration of two 5-hydroxytryptamine precursors in normal man.
Six healthy male subjects received equimolar amounts of two 5-hydroxytryptamine (5-HT) precursors, 5-hydroxy-L-tryptophan (5-HTP) and gamma-L-glutamyl-5-hydroxy-L-tryptophan (glu-5-HTP), on two occasions in a randomised cross-over study. There were marked increases in urinary 5-HTP and 5-HT excretion after infusion of both compounds. Mean urinary excretion rate of 5-HT, which was < 0.7 nmol min...
متن کاملIncrease in brain tryptophan and 5-hydroxytryptamine on administration of phenothiazines to rats.
A major factor regulating the synthesis of the neurotransmitter 5-hydroxytryptamine in the brain is the availability of the precursor amino acid, tryptophan. The K, of tryptophan hydroxylase (L-tryptophan mono-oxygenase, EC 1.14.16.4) is of the same order of magnitude as the brain concentration of tryptophan (Gal, 1974). Uptake of tryptophan into the brain is believed to be regulated by that fr...
متن کاملRelationship between neonatal testosterone and 5-hydroxytryptamine (5 HT) in controlling the pattern of LH release in adult rats
Relationship between neonatal testosterone and 5-hydroxytryptamine (5-HT) in controlling the pattern of LH release in adult rats was investigated in this study. Hypothalamic 5-HT concentrations are transiently lower in male as compared to female Wistar rats in the second week post-partum (pp). It has also been shown that pharmacologically potentiating 5-HT activity during this period feminizes ...
متن کاملEffect of Maternal Pyridoxine Ingestion on Cord Blood 5 - Hydroxytryptamine Concentration JULIAN
Newborn infants have relatively low levels of circulating 5-hydroxytryptamine (5HT, serotonin) when compared with adults or children (Mitchell and Cass, 1959; Hazra, Benson, and Sandler, 1965). Values in cord blood are similarly low (R. S. Stacey, 1965, personal communication). Berman, Justice, and Hsia (1965) have confirmed these findings in low birth weight and full-term newborn infants and h...
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 1973
ISSN: 0306-3283
DOI: 10.1042/bj1340763